Research Studies

Status: Completed
Study area: Nutrition/Dietary, Other
Principal investigator: McCrory MA, Saltzman E, Rolls BJ, Roberts SB
Project period: 2006

The relative effects of energy density and palatability on energy intake, and whether there are familial influences on these effects, are not known.

Status: Completed
Study area: Other
Principal investigator: Messner DJ, Romeo C, Boynton A, Rossie S
Project period: 2006

The microbial toxin okadaic acid (OA) specifically inhibits PPP-type ser/thr protein phosphatases. OA is an established tumor promoter with numerous cellular effects that include p53-mediated cell cycle arrest.

Status: Completed
Study area: Botanical Medicine, Healthy Aging
Principal investigator: Newton KM, Reed SD, LaCroix AZ
Co-investigator(s): Newton KM, Reed SD, LaCroix AZ, Grothaus LC, Ehrlich K, Guiltinan J
Project period: 2006

Black cohosh used in isolation, or as part of a multibotanical regimen, shows little potential as an important therapy for relief of vasomotor symptoms. Clinical Trials Registration number: NCT00169299

Status: Completed
Study area: CAM Research / Education
Principal investigator: Standish, Calabrese, Snider, Kail, Mills, Myers, Traub, and Zwic
Project period: 2006
Status: Completed
Study area: Nutrition/Dietary, General Wellness
Co-investigator(s): Lefevre M, Lovejoy JC, Smith SR, Delany JP, Champagne C, Most MM, Denkins Y, de Jonge L, Rood J, Bray GA
Funded by: Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA. lefevrm@pbrc.edu
Project period: 2005

Trans-fatty acids have been implicated as a risk factor for cardiovascular disease and diabetes. In addition, a polymorphism at codon 54 (Ala54Thr) in the fatty acid-binding protein 2 (FABP2) gene has been suggested to modify an interaction between dietary fat and insulin sensitivity.

Status: Completed
Study area: Nutrition/Dietary, General Wellness
Co-investigator(s): Parks EJ, McCrory MA
Project period: 2005
Status: Completed
Study area: Neurology
Co-investigator(s): Richards TL, Kozak L, Johnson LC, Standish LJ.
Funded by: Department of Radiology, University of Washington, Seattle, WA 98195, USA.
Project period: 2005

 

Status: Completed
Study area: Nutrition/Dietary, Healthy Aging
Co-investigator(s): Roberts SB, Hajduk CL, Howarth NC, Russell R, McCrory MA
Funded by: The Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
Project period: 2005

In contrast to previous suggestions that older persons consume a monotonous diet, this study showed that adults who were 61 years or older consumed a greater total food variety, and a greater variety of micronutrient-dense and energy-weak foods, compared with adults who were 60 years or younger. Although consumption of a low variety of energy-dense foods may contribute to reduced energy intake and body weight at any age, the variety of micronutrient-dense foods consumed needs to increase in old age to prevent micronutrient deficiencies. These findings suggest that all adults need advice on the changing needs for dietary variety with aging to maintain health, and that older persons with low BMI are particularly vulnerable to dietary shortfalls.

Status: Completed
Study area: Nutrition/Dietary, General Wellness
Co-investigator(s): Tulley RT, Vaidyanathan J, Wilson JB, Rood JC, Lovejoy JC,, Most MM, Volaufova J, Peters JC, Bray GA
Funded by: Pennington Biomedical Research Center, Baton Rouge, LA 70112, USA. rtulley@agcenter.lsu.edu
Project period: 2005

The objective of this study was to determine whether vitamin supplementation during long-term (36 wk) ingestion of olestra supplemented with vitamin E could prevent decreases in vitamin E, vitamin A, and carotenoids.

Status: Completed
Study area: General Wellness
Co-investigator(s): Veldhuis JD, Roemmich JN, Richmond EJ, Rogol AD, Lovejoy JC, , Sheffield-Moore M, Mauras N, Bowers CY.
Funded by: Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA. veldhuis.johannes@mayo.edu
Project period: 2005

Body composition exhibits marked variations across the early human lifetime. The precise physiological mechanisms that drive such developmental adaptations are difficult to establish.

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