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A Comparative Effectiveness Trial of High-Quality Vitamin D3 Nutritional Supplements to Replete Serum Vitamin D
The importance of vitamin D in the prevention and treatment of diabetes and cardiovascular disease has gained increased attention in recent years. There is a need to determine what forms of vitamin D may be supplemented to correct vitamin D insufficiency and to elucidate possible mechanisms by which vitamin D sufficiency may decrease risk for developing diabetes. This randomized clinical trail will compare the effects of three different vitamin D supplements to correct insufficiency and will determine the effects of vitamin D repletion on the expression of the Klotho protein.